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Paracoccidioides brasiliensis: Cell Wall Glucans, Pathogenicity, and Dimorphism

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Current Topics in Medical Mycology

Part of the book series: Current Topics in Medical Mycology ((CT MYCOLOGY,volume 1))

Abstract

Paracoccidioidomycosis is one of the several systemic fungal diseases that afflict humans. Geographically, it is confined to Latin America, with its endemic areas extending from Central America down to Argentina. Humans, apparently are the only hosts susceptible to natural infection by its etiologic agent, Paracoccidioides brasiliensis. Although almost 80 years have elapsed since the dimorphic nature of P. brasiliensis was first described by Lutz (1908), our knowledge of the biological events that take place in this process has been acquired very slowly; even at present, many important questions still remain unanswered (1).

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References

  1. Ajello L: Preface, in Del Negro G, Lacaz CD, Fiorello AM (eds): Paracoccidioidomicose, Blastomicose Sul-Americana. São Paulo, Brazil, SarvierEdusp., 1982.

    Google Scholar 

  2. Azuma I, Kanetsuna F, Tanaka Y, Yamamura Y, Carbonell LM: Chemical and immunological properties of galactomannans obtained from Histoplasma duboisii, Histoplasma capsulatum, Paracoccidioides brasiliensis, and Blastomyces dermatitidis. Mycopathol Mycol Appl 54: 111–125, 1974.

    Article  PubMed  CAS  Google Scholar 

  3. Baguley B, Rommele G, Gruner J, Wehrli W: Papulacandin B: An inhibitor of glucan synthesis in yeast spheroplasts. Eur J Biochem 97: 345–351, 1979.

    Article  PubMed  CAS  Google Scholar 

  4. Bartnicki-García S: Cell wall chemistry, morphogenesis, and taxonomy of fungi. Ann Rev Microbiol 22: 87–108, 1968.

    Article  Google Scholar 

  5. Cabib E, Roberts R, Bowers B: Synthesis of the yeast cell wall and its regulation. Ann Rev Biochem 51: 763–793, 1982.

    Article  PubMed  CAS  Google Scholar 

  6. Carbonell LM, Gil F: Ultraestructura del Paracoccidioides brasiliensis, in Del Negro G, Lacaz CD, Fiorello AM (eds): Paracoccidioidomicose, Blastomicose Sul-Americana. São Paulo, Brazil, Sarvier-Edusp., 1982, pp 23–34.

    Google Scholar 

  7. Carbonell LM, Kanetsuna F, Gil F: Chemical morphology of glucan and chitin in the cell wall of the yeast phase of Paracoccidioides brasiliensis. J Bacteriol 101: 636–642, 1970.

    CAS  Google Scholar 

  8. DiSalvo A, Denton JF: Lipid content of four strains of Blastomyces dermatitidis of different mouse virulence. J Bacteriol 85: 927–931, 1963.

    PubMed  CAS  Google Scholar 

  9. Domer JE: Monosaccharide and chitin content of cell walls of Histoplasma capsulatum and Blastomyces dermatitidis. J Bacteriol 107: 870–877, 1971.

    CAS  Google Scholar 

  10. Fromtling RA, Shadomy HJ, Jacobson ES: Increased virulence in stable, acapsular mutants of Cryptococcus neoformans. Mycopathologia 79: 23–29, 1982.

    Article  CAS  Google Scholar 

  11. Goihman-Yahr M, Essenfeld-Yahr E, Albornoz MQ Yarzâbal L, De Gómez MH, San Martin B, Ocanto A, Gil F, Convit J: Defect of in vitro digestive ability of polymorphonuclear leukocytes in paracoccidioidomycosis. Infect Immun 28: 557–566, 1980.

    PubMed  CAS  Google Scholar 

  12. Grunner J, Traxler P: Papulacandin, a new antibiotic active specifically against yeasts. Experientia 33: 137, 1977.

    Article  Google Scholar 

  13. Hallak H, San-Blas F, San-Blas G: Isolation and wall analysis of dimorphic mutants of Paracoccidioides brasiliensis. Sabouraudia 20: 51–62, 1982.

    CAS  Google Scholar 

  14. Inlow DI: Estudios sobre el dimorfismo en Paracoccidioides brasiliensis. Tesis de Magister Scientiarum, IVIC, Caracas, Venezuela, 1979.

    Google Scholar 

  15. Ishaf CM, Bulmer GS, Felton FG: An evaluation of various environmental factors affecting the propagation of Cryptococcus neoformans. Mycopathol Mycol Appl 35: 81–90, 1968.

    Article  Google Scholar 

  16. Kanetsuna F: Ultrastructural studies on the dimorphism of Paracoccidioides brasiliensis, Blastomyces dermatitidis, and Histoplasma capsulatum. Sabouraudia 19: 275–286, 1981.

    Article  CAS  Google Scholar 

  17. Kanetsuna F, Carbonell LM: Cell wall composition of the yeast-like and mycelial forms of Blastomyces dermatitidis. J Bacteriol 106: 946–948, 1971.

    CAS  Google Scholar 

  18. Kanetsuna F, Carbonell LM, Azuma I, Yamamura Y: Biochemical studies on thermal dimorphism of Paracoccidioides brasiliensis. J Bacteriol 110: 208–218, 1972.

    PubMed  CAS  Google Scholar 

  19. Kanetsuna F, Carbonell LM, Moreno RE, Rodriguez J: Cell wall composition of the yeast and mycelial forms of Paracoccidioides brasiliensis. J Bacteriol 97: 1036–1041, 1969.

    CAS  Google Scholar 

  20. Keller FA, Cabib E: Chitin and yeast budding. Properties of chitin synthetase from Saccharomyces cerevisiae. J Biol Chem 246: 160–166, 1971.

    CAS  Google Scholar 

  21. López-Romero E, Ruíz-Herrera J: Synthesis of chitin by particulate preparations from Aspergillus flavus. Antonie van Leeuwenhoek. J Microbiol Serol 42: 261–276, 1976.

    Article  Google Scholar 

  22. Lutz A: Uma mycose pseudococcidica localisada na bocca e observada no Brazil. Contribuiçao ao conhecimiento dos hyphoblastomycoses americanas. Brasil-Méd 22: 121–124, 1908.

    Google Scholar 

  23. Nickerson WJ, Edwards GA: Studies on the physiological bases of morpho-genesis in fungi. I. The respiratory metabolism of dimorphic pathogenic fungi. J Gen Physiol 33: 41–55, 1949.

    Article  PubMed  CAS  Google Scholar 

  24. Pérez P, Varona R, García-Acha I, Duran A: Effect of papulacandin B and aculeacin A on ß-1,3-glucan synthetase from Geotrichum lactis. FEBS Lett 129: 249–252, 1981.

    Article  Google Scholar 

  25. Ruiz-Herrera J, López-Romero E, Bartnicki-García S: Properties of chitin synthetase in isolated chistosomes from yeast cells of Mucor rouxii. J Biol Chem 252: 3338–3343, 1977.

    CAS  Google Scholar 

  26. San-Blas F, Centeno S: Isolation and preliminary characterization of auxotophic and morphological mutants of the yeast-like form of Paracoccidioides brasiliensis. J Bacteriol 129: 138–144, 1977.

    CAS  Google Scholar 

  27. San-Blas F, San-Blas G: Bioquimica y dimorfismo en Paracoccidioides brasiliensis, in Del Negro G, Lacaz CD, Fiorello AM (eds): Paracoccidioidomicose, Blastomicose Sul-Americana. São Paulo, Brazil, Sarvier-Edusp., 1982, pp 35–58.

    Google Scholar 

  28. San-Blas F, San-Blas G: Paracoccidioides brasiliensis,in Szanizslo PS (ed): Fungal Dimorphism: With Emphasis on Fungi Pathogenic to Humans. New York, Academic Press (in press, 1985).

    Google Scholar 

  29. San-Blas F, San-Blas G, Cova LJ: A morphological mutant of Paracoccidioides brasiliensis strain IVIC Pb9. Isolation and wall characterization. J Gen Microbiol 93: 208–218, 1976.

    Google Scholar 

  30. San-Blas F, San-Blas G, Hallak J, Merino E: Ultrastructural and cell wall chemistry of a thermosensitive mutant of Paracoccidioides brasiliensis. Curr Microbiol 8: 85–88, 1983.

    Article  CAS  Google Scholar 

  31. San-Blas F, San-Blas G, Inlow D: Dimorphism in Paracoccidioides brasiliensis, in Preusser JH (ed): Medical Mycology, Selected Proceedings of Mycological Symposia of the XII International Congress of Microbiology. Zentralbi Bakteriol Hygiene Supplements 1980, vol 8, pp 23–28.

    Google Scholar 

  32. San-Blas G: Biosynthesis of glucans by subcellular fractions of Paracoccidioides brasiliensis. Exp Mycol 3: 249–258, 1979.

    Article  CAS  Google Scholar 

  33. San-Blas G, San-Blas F: Paracoccidioides brasiliensis: Cell wall structure and virulence. A review. Mycopathologia 62: 77–86, 1977.

    Article  PubMed  CAS  Google Scholar 

  34. San-Blas G, San-Blas F: Estudio comparativo de la actividad de glucan sintetasa en dose cepas de Paracoccidioides brasiliensis. Acta Cient Venez 33: 327–332, 1982b.

    CAS  Google Scholar 

  35. San-Blas G, San-Blas F: Effect of detergents on membrane-associated glu-can synthetase from Paracoccidioides brasiliensis. J Bacteriol 152: 563–566, 1982c.

    CAS  Google Scholar 

  36. San-Blas G, San-Blas F, Ormaechea E, Serrano LE: Cell wall analysis of an adenine-requiring mutant of the yeast-like form of Paracoccidioides brasiliensis strain IVIC Pb9. Sabouraudia 15: 297–303, 1977a.

    Article  PubMed  CAS  Google Scholar 

  37. San-Blas G, San-Blas F, Serrano LE: Host-parasite relationships in the yeast-like form of Paracoccidioides brasiliensis strain IVIC Pb9. Infect Immun 15: 343–346, 1977b.

    PubMed  CAS  Google Scholar 

  38. San-Blas G, Vernet D: Induction of the synthesis of cell wall a-1,3-glucan in the yeastlike form of Paracoccidioides brasiliensis strain IVIC Pb9 by fetal calf serum. Infect Immun 15: 897–902, 1977.

    PubMed  CAS  Google Scholar 

  39. Temin HM, Pierson RW, Dulak NC: The role of serum in the control of multiplication of avians and mammalian cells in the culture, in Rothblat GH, Cristofalo VJ (eds): Growth, Nutrition and Metabolism of Cells in Culture. New York, Academic Press, 1972, pp 49–81.

    Google Scholar 

  40. Zonneveld BJM: α-1,3-glucan synthesis correlated with α-1,3-glucanase synthesis, conidiation, and fructification in morphogenetic mutants of Aspergillus nidulans. J Gen Microbiol 81:445–451, 1974.

    PubMed  CAS  Google Scholar 

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San-Blas, G. (1985). Paracoccidioides brasiliensis: Cell Wall Glucans, Pathogenicity, and Dimorphism. In: McGinnis, M.R. (eds) Current Topics in Medical Mycology. Current Topics in Medical Mycology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9547-8_9

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  • DOI: https://doi.org/10.1007/978-1-4613-9547-8_9

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