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Animal Models for Candidiasis

  • Chapter
Current Topics in Medical Mycology

Part of the book series: Current Topics in Medical Mycology ((CT MYCOLOGY,volume 1))

Abstract

Members of the genus Candida, particularly C. albicans, are frequent human pathogens that have increased in importance with advances in modern medicine and chemotherapy. Candida albicans in the yeast form may occur in small numbers on the mucous membranes of the alimentary tract or vagina of healthy human hosts; but, they may be the etiologic agent of disease in virtually any tissue of the body of the compromised host (186). The most common manifestations of candidiasis (or candidosis) involve superficial infections of the skin or the mucous membranes of the mouth and vagina. Odds (186) for example, in his extensive review of the literature, has estimated that oral thrush may occur in approximately 5% of neonates, candidal-associated palatal stomatitis in as many as 60% of elderly denture wearers, and vaginal thrush in approximately 5% of obstetric and gynecologic outpatients. Advances in the medical sciences have led to increases in both the incidence and spectrum of severity of candidiasis. For example, Candida is a frequent cause of either superficial lesions of epithelial surfaces or a generalized systemic mycosis in patients who are undergoing chemotherapy for cancer (55, 218, 315), immunosuppressive treatment for organ transplants (43), surgery (67), and prolonged oral antibiotic medication (74, 257); or, in patients suffering from immune deficiency diseases (34, 43, 210, 212, 302), including the newly recognized epidemic illness of acquired immunodeficiency syndrome (AIDS) (73).

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Authors
  1. M. Neal Guentzel
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  2. Garry T. Cole
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  3. Leodocia M. Pope
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  1. Department of Microbiology and Immunology, Chapel Hill, North Carolina, USA

    Michael R. McGinnis

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Guentzel, M.N., Cole, G.T., Pope, L.M. (1985). Animal Models for Candidiasis. In: McGinnis, M.R. (eds) Current Topics in Medical Mycology. Current Topics in Medical Mycology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9547-8_3

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