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Current Topics in Medical Mycology pp 24–56Cite as

Composition and Structure of Yeast Cell Walls

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Part of the book series: Current Topics in Medical Mycology ((CT MYCOLOGY,volume 1))

Abstract

Stimulus for research in the chemistry of yeast cell walls has come from both fundamental and applied directions. Fundamental knowledge of the yeast cell wall has contributed significantly to a better understanding at the molecular level of basic cellular reactions, such as growth and morphogenesis (15, 19, 20), sexual mating (59, 171), protoplast formation (6, 146), autolysis (7), and cell flocculation (2, 126). Medical interest in the walls of yeast cells has mainly developed because of the importance of Candida albicans and Cryptococcus neoformans (1), where it is being increasingly realized that certain aspects of their pathogenicity can be related to cell wall composition and structure. The role of the cell wall in the pathogenicity of various yeast and other fungal species has recently been reviewed by San-Blas (163), who points out that the wall is the primary site of contact between host and pathogen. The antigenic and chemical properties of yeast cell walls are now exploited in the clinical diagnosis of yeast infections (98). The responses of yeasts to antibiotic therapy, in some cases, can have their origins in the walls (75); this has generated further interest in studying cell wall chemistry. Lastly, the interesting behavior of some components of yeast cell walls as antitumor agents (185) or as stimulators of the immune system (90, 140) demand explanation at the chemical level.

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  1. Graham H. Fleet
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  1. Department of Microbiology and Immunology, Chapel Hill, North Carolina, USA

    Michael R. McGinnis

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Fleet, G.H. (1985). Composition and Structure of Yeast Cell Walls. In: McGinnis, M.R. (eds) Current Topics in Medical Mycology. Current Topics in Medical Mycology, vol 1. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9547-8_2

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